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Rare Copy Number Variants and Risk of Depression

Key clinical point: Neurodevelopmental copy variants (CNVs) may be associated with depression.

Major finding: Neurodevelopmental disorder CNVs appeared to be associated with the risk of depression in those without neurodevelopmental disorders.

Study details: A case-control study of 407,074 individuals from the UK Biobank study conducted from January 2017 to September 2018.

Disclosures: Dr. Kendall reported receiving grants from Wellcome Trust and grants from the Medical Research Council (MRC) during the conduct of the study. Dr. Bracher-Smith reported receiving grants from the MRC during the conduct of the study. Drs. O'Donovan, Owen, and Walters reported receiving grants from the MRC during the conduct of the study and grant MR/P005748/1 for molecular genetic studies of schizophrenia; and reported receiving grants from Takeda Pharmaceuticals outside of the submitted work.

Citation:

Kendall KM, et al. JAMA Psychiatry. 2019 Apr 17. doi: 10.1001/jamapsychiatry.2019.0566.