Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Prenatal Maternal Mood and Child’s Mental Health

J Affect Disord; ePub 2017 Nov 14; Glynn, Howland, et al

There is strong support for the notion that patterns of maternal mood influence the developing brain, according to a recent study. More specifically, it is suggested that prenatal maternal mood predictability may be a critical predictor of developmental mental health trajectories and should be considered when assessing early life influences on lifespan mental health. The association between prenatal mood predictability and child internalizing symptoms were assessed in 2 longitudinal cohorts (n=227 and 180). Maternal mood was assessed repeatedly during pregnancy as early as 15 weeks’ gestation; maternal reports of child negative affectivity were collected at 6, 12, 24 months, and at age 7 years. Researchers found:

  • Fetal exposure to more elevated maternal mood entropy predicted higher levels of child negative affectivity at 12 months, 24 months, and 7 years.
  • In addition, children exposed to higher prenatal maternal mood entropy, reported higher levels of anxiety symptoms at 10 years and elevated depressive symptoms at 13 years.
  • These associations persisted after adjusting for maternal pre and postnatal mood valence and for other relevant demographic characteristics.


Glynn LM, Howland MA, Sandman CA, et al. Prenatal maternal mood patterns predict child temperament and adolescent mental health. [Published online ahead of print November 14, 2017]. J Affect Disord. doi:10.1016/j.jad.2017.11.065.

This Week's Must Reads

Early Intervention Backed for Early-phase Psychosis, JAMA Psychiatry; ePub 2018 May 2; Correll, et al

Cultural Disparities Among Social Support Seekers, Psychiatry Res; ePub 2018 May 6; Herbert, et al

Caffeine May Promote Early Use of Other Substances, Addiction; ePub 2018 Apr 30; Krisjansson, et al

Relationship Between Schizotypal Traits, Hoarding , J Affect Disord; ePub 2018 May 4; Weintraub, et al

Defining Sexual Wellness in Mid- and Later Life, J Sex Res; ePub 2018 Apr 18; Syme, Cohn, et al

Must Reads in Depression

Examining PTSD, Depression, and Suicide in Veterans, Psychiatry Res; ePub 2018 Apr 22; Arenson, et al

Insomnia Mediates Anxiety-Depression Relationship, Depress Anxiety; ePub 2018 Apr 26; Li, Starr, et al

Bullying by Peers and Mental Health in Adolescence, JAMA Psychiatry; ePub 2018 Apr 11; Lee, et al

Age, Sex Factor into Firearm Use in Suicide Deaths, J Affect Disord; ePub 2018 Apr 21; Kalesan, et al

Combat Exposure, Suicidal Behavior Linked via PTSD, J Affect Disord; ePub 2018 Apr 10; Dillon, et al