Clinical Edge

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Plasma Levels of IL-6 Higher in Major Depressive Disorder

Key clinical point: Contrary to their hypothesis, the researchers found no correlations between plasma Interleukin-6 (IL-6) levels and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) or homovanillic acid (HVA) in patients with major depressive disorder.

Major finding: Plasma IL-6 levels were significantly higher in patients with major depressive disorder, compared with healthy controls (3.11 ng/mL vs. 2.69 ng/mL), and those levels were positively correlated with scores on the 17-item Hamilton Depression Rating Scale.

Study details: The data come from 148 adults with major depressive disorder and 40 healthy controls.

Disclosures: The researchers had no financial conflicts to disclose.


Yoshimura R et al. Neuropsychiatr Dis Treat. 2019. doi: 10.2147/NDT.S195379.