Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Mood Disorders and BMI/Overweight Associated

J Affect Disord; ePub 2019 Jan 15; Glaus, et al

Overweight may be either a precursor or consequence of atypical depression rather than a manifestation of a common diathesis underlying depression in families, according to a recent study. Therefore, clinicians should pay particular attention to this subtype that could be at increased risk for the development of cardiovascular risk factors and diseases. The sample included 293 probands recruited from the community and their 544 adult first-degree relatives. Diagnostic assignment was based on a direct semi-structured interview. Mixed effect models were employed to test the familial aggregation and the familial cross-aggregation of mood disorders and body mass index (BMI)/overweight. Researchers found:

  • There were significant within-individual associations between overweight and the atypical subtype of depression.
  • There was also an association for BMI/overweight between probands and relatives.
  • Atypical depression in probands was significantly associated with BMI and overweight in relatives.


Glaus J, Cui L, Hommer R, Merikangas KR. Association between mood disorders and BMI/overweight using a family study approach. [Published online ahead of print January 15, 2019]. J Affect Disord. doi:10.1016/j.jad.2019.01.011.