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Inflammation Associated with Suicide Ideation

J Affect Disord; ePub 2018 Nov 6; Mezuk

Dietary inflammatory potential was associated with suicide ideation (SI) among US adults with and without depression, according to a recent study. However, findings did not support inflammatory factors having a relationship with suicide ideation distinct from depression. Data came from multiple cycles of the US National Health and Nutrition Examination Survey (C-reactive protein [CRP] and white blood cell [WBC] count: n=13,912; Dietary Inflammatory Index [DII]: n=17,076; immunoglobulin E [IgE]=4,060]). Major depression (MD) was measured using the Patient Health Questionnaire-9 (PHQ-9); SI was indicated by the last item of the PHQ-9. To assess SI independent from MD, participants were classified into 4 categories: SI with MD, SI without MD, MD without SI, and neither MD nor SI. Researchers found:

  • None of the inflammatory indicators were able to distinguish SI status among MD cases.
  • DII was associated with SI among individuals without MD.
  • CRP, DII, and WBC were associated with MD.
  • No associations were found for IgE.


Mezuk B. Inflammation as a unique marker of suicide ideation distinct from depression syndrome among U.S. adults. [Published online ahead of print November 6, 2018]. J Affect Disord. doi:10.1016/j.jad.2018.11.046.