Clinical Edge

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Identifying MDD Patients for Next-Step Treatments

J Affect Disord; ePub 2016 Jul 27; Zisook, Tal, et al

Treating major depressive disorder (MDD) often necessitates evidence based on “next-step” treatments, a recent study found, and characterizing patients requiring next steps may lead to tailored approaches. Researchers examined 1,522 US veteran outpatients with nonpsychotic MDD who completed assessments prior to being randomized. Data was summarized and presented in terms of demographic, social, historical, and clinical features and compared to a similar non-veteran sample. They found:

• Participants, largely male and white, were moderately depressed, with about one-third reporting suicidal ideation.

• More than half had chronic and/or recurrent depression.

• General medical and psychiatric comorbidities were highly prevalent, particularly posttraumatic stress disorder.

• Many had histories of childhood adversity and bereavement.

Citation: Zisook S, Tal I, Weingart K, et al. Characteristics of U.S. veteran patients with major depressive disorder who require “next-step” treatments: A VAST-D report. [Published online ahead of print July 27, 2016]. J Affect Disord. doi:10.101/j.jad.2016.07.023.