Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Collaborative Intervention for Obesity, Depression

JAMA; 2019 Mar 5; Ma, Goldman Rosas, Lv, et al

Among adults with obesity and depression, a collaborative care intervention integrating behavioral weight loss treatment, problem-solving therapy, and as-needed antidepressant medications significantly improved weight loss and depressive symptoms at 12 months, compared with usual care, according to a recent study. The Research Aimed at Improving Both Mood and Weight (RAINBOW) randomized clinical trial enrolled 409 adults with body mass indices (BMIs) of ≥30 (≥27 for Asian adults) and 9-item Patient Health Questionnaire (PHQ-9) scores of ≥10. Researchers found:

  • Among 409 participants randomized (70% were women; mean BMI of 36.7 [SD, 6.4]; mean PHQ-9 score of 13.8 [SD, 3.1]; and mean Symptom Checklist Depression Scale (SCL-20) score of 1.5 [SD, 0.5]), 344 (84.1%) completed 12-month follow-up.
  • At 12 months, mean BMI declined from 36.7 (SD, 6.9) to 35.9 (SD, 7.1) among intervention participants compared with a change in mean BMI from 36.6 (SD, 5.8) to 36.6 (SD, 6.0) among usual care participants.
  • Mean SCL-20 score declined from 1.5 (SD, 0.5) to 1.1 (SD, 1.0) at 12 months among intervention participants compared with a change in mean SCL-20 score from 1.5 (SD, 0.6) to 1.4 (SD, 1.3) among usual care participants.
Citation:

Ma J, Goldman Rosas L, Lv N, et al. Effect of integrated behavioral weight loss treatment and problem-solving therapy on body mass index and depressive symptoms among patients with obesity and depression. The RAINBOW randomized clinical trial. JAMA. 2019;321(9):869-879. doi:10.1001/jama.2019.0557.

This Week's Must Reads

Family Involvement in Veterans with Schizophrenia, Psychiatr Rehabil J; ePub 2019 Mar 28; Cohen, et al

Cognitive Training Program in Schizophrenia, Schizophr Res; ePub 2019 Mar 28; Mahncke, et al

Continuous Exercise & CI in Schizophrenia, Front Psychiatry; ePub 2019 Mar 13; Herbsleb, et al

MHC Risk Variants in Cortical Thickness, Brain Behav; ePub 2019 Mar 28; Tao, et al

Disclosing the Diagnosis of Schizophrenia, Int J Soc Psychiatry; ePub 2019 Mar 27; Setti, et al

Must Reads in Depression

Early-Life Stress Linked with Cytomegalovirus in MDD , JAMA Psychiatry; ePub 2019 Mar 6; Ford, et al

Collaborative Intervention for Obesity, Depression , JAMA; 2019 Mar 5; Ma, Goldman Rosas, Lv, et al

Body Weight Predicts Risk for Depressive Symptoms , J Affect Disord; ePub 2019 Mar 5; Vittengl

Slow-Wave Activity and Mood Disturbance in MDD, Psychol Med; 2019 Mar; Goldschmied, et al