Clinical Edge

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Opioids, Benzodiazepines Carry Greater Risk of COPD-Related Hospitalization

Key clinical point: Patients with COPD are at greater risk for hospitalization because of respiratory-related adverse events.

Major finding: In the 30 days before COPD-related hospitalization, use of opioids (adjusted odds ratio, 1.73; 95% confidence interval, 1.52-1.97), use of benzodiazepines (aOR, 1.42; 95% CI, 1.21-1.66), and use of both opioids and benzodiazepines carried a significantly higher risk of hospitalization (aOR, 2.32; 95% CI, 1.94-2.77).

Study details: A Medicare database case-control study of 3,232 patients with COPD receiving opioids or benzodiazepines who were hospitalized for respiratory-related adverse events in 2014.

Disclosures: This study was supported by an award from the National Center for Advancing Translational Sciences and National Institutes of Health. Dr. Baillargeon had no disclosures.


Baillargeon JG et al. Ann Am Thorac Soc. 2019 Oct 1. doi: 10.1513/AnnalsATS.201901-024OC.