Key clinical point: Stress-induced frontal lobe activity was associated with self-reported angina symptoms in patients with heart disease.
Major finding: Any doubling in inferior frontal lobe activation led to an increase in angina frequency by 13.7 units at baseline (95% CI, 6.3-21.7; P = .008) and 11.6 units during follow-up (95% CI, 4.1-19.2; P = .01).
Study details: A study of 148 patients with stable coronary artery disease.
Disclosures: The study was supported by grants from the National Institutes of Health. The authors reported no potential conflicts of interest.
Moazzami K et al. Circ Cardiovasc Imaging. 2020 Aug 10. doi: 10.1161/circimaging.120.010710.