Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Subthreshold Pediatric BD Linked with Suicide Risk

Bipolar Disord; ePub 2018 Nov 27; Vaudreuil, et al

Subthreshold pediatric bipolar disorder (BD) is an identifiable morbid condition associated with significant functional impairment including psychiatric comorbidities and high rates of suicidality, according to a recent systematic review. Researchers included studies examining the morbidity of pediatric subthreshold BD. Extracted outcomes included functional impairment, severity of mood symptoms, psychiatric comorbidities, suicidal ideation and behaviors, and mental health treatment. 11 papers, consisting of 7 datasets, were included. Researchers compared subthreshold pediatric BD (n=244) to non‐bipolar controls (n=1,125) and subthreshold pediatric BD (n=643) to pediatric BD‐I (n=942). They found:

  • Subthreshold pediatric BD was associated with greater functional impairment, greater severity of mood symptomatology, higher rates of disruptive behavior, mood, and substance use disorders, and higher rates of suicidal ideation and attempts compared to controls.
  • Pediatric BD‐I was associated with greater functional impairment, greater severity of manic symptoms, higher rates of suicidal ideation and attempts, and higher rates of mental health treatment compared to subthreshold pediatric BD.
  • There were no differences between full and subthreshold cases in the severity of depressive symptoms or rates of comorbid disorders.
Citation:

Vaudreuil CAH, Faraone SV, Di Salvo M, et al. The morbidity of subthreshold pediatric bipolar disorder: A systematic literature review and meta‐analysis. [Published online ahead of print November 27, 2018]. Bipolar Disord. doi:10.1111/bdi.12734.

This Week's Must Reads

Cognition Impairment a Familial Disposition of MDD, JAMA Psychiatry; ePub 2018 Dec 26; Mackenzie, et al

Cognition in MDD and Aberrant Network Connectivity, J Psychiatr Res; 2019 Mar; Albert, Potter, Boyd, et al

Partner Criticism During Therapy for Recurrent MDD, Behav Res Ther; ePub 2018 Dec 21; Vittengl, et al

Study: Predictions of MDD Are Multifactorial, Depress Anxiety; ePub 2018 Dec 5; van Bronswijk, et al

Linguistic Analysis of Memories of People with MDD, PLoS One; ePub 2018 Nov 26; Himmelstein, et al

Must Reads in Bipolar Disorder

BD Course Strongly Affected by Comorbid Disorders, J Affect Disord; ePub 2018 Dec 25; Weintraub, et al

Differentiating Borderline Personality from BD, Compr Psychiatry; 2019 Jan; Balling, et al

Bipolar Diathesis in Major Depression Disorder , J Affect Disord; ePub 2018 Nov 2; Bennett, et al

Expressed Emotion Among Parents of Youths with BD, Psychiatry Res; 2018 Dec; Millman, Weintraub, et al

Predicting Risk of Conversion from Mania to BD I/II , J Am Acad Child Adolesc Psychiatry; 2018 Oct; Birmaher, et al