The relationship between neurocognition and community functioning in bipolar disorder (BD) may be dependent on social cognition status, implying the presence of social cognitive heterogeneity, a recent study found. 200 BD patients and 49 healthy controls (HC) were administered and compared on a battery of tests assessing neurocognition, social cognition, and community functioning. Researchers conducted a series of regression analyses to investigate potential mediation or moderation of social cognition on the relationship between neurocognition and community functioning. They found:
- BD patients performed worse on neurocognitive domains of processing speed, attention, verbal learning, and global neurocognition.
- Also, BD patients performed worse on theory of mind, the social cognition composite score, and community functioning.
- Neurocognition did not significantly predict functional outcome in the BD sample.
- However, a moderating effect of social cognition was discovered: Among patients with poor social cognition, better neurocognition was associated with better community functioning, a relationship not seen in BD patients with good social cognition.
Ospina LH, Nitzburg GC, Shanahan M, Perez-Rodriguez MM, et al. Social cognition moderates the relationship between neurocognition and community functioning in bipolar disorder. [Published online ahead of print March 29, 2018]. J Affect Disord. doi:10.1016/j.jad.2018.03.013.
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