Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Social Cognition Status Effect on Bipolar Disorder

J Affect Disord; ePub 2018 Mar 29; Ospina, et al

The relationship between neurocognition and community functioning in bipolar disorder (BD) may be dependent on social cognition status, implying the presence of social cognitive heterogeneity, a recent study found. 200 BD patients and 49 healthy controls (HC) were administered and compared on a battery of tests assessing neurocognition, social cognition, and community functioning. Researchers conducted a series of regression analyses to investigate potential mediation or moderation of social cognition on the relationship between neurocognition and community functioning. They found:

  • BD patients performed worse on neurocognitive domains of processing speed, attention, verbal learning, and global neurocognition.
  • Also, BD patients performed worse on theory of mind, the social cognition composite score, and community functioning.
  • Neurocognition did not significantly predict functional outcome in the BD sample.
  • However, a moderating effect of social cognition was discovered: Among patients with poor social cognition, better neurocognition was associated with better community functioning, a relationship not seen in BD patients with good social cognition.

Citation:

Ospina LH, Nitzburg GC, Shanahan M, Perez-Rodriguez MM, et al. Social cognition moderates the relationship between neurocognition and community functioning in bipolar disorder. [Published online ahead of print March 29, 2018]. J Affect Disord. doi:10.1016/j.jad.2018.03.013.

This Week's Must Reads

Depression May Be Linked with SLE Risk in Women, JAMA Psychiatry; ePub 2018 Sep 12; Roberts, et al

Women with MDD During the Childbearing Years, Depress Anxiety; ePub 2018 Sep 7; Freeman, et al

Resilience Examined in Older Adults with Depression, Am J Geriatr Psychiatry; ePub 2018 Aug 25; Laird, et al

Disparities in Depression Care Among Arab Americans, Depress Anxiety; ePub 2018 Aug 12; Dallo, et al

Telehealth vs In-Person Care for Depressed Veterans, J Clin Psychiatry; 2018 Aug 28; Egede, et al

Must Reads in Bipolar Disorder

Bipolar Illness and Multigenerational Transmission, Bipolar Disord; ePub 2018 Jun 21; Post, Altshuler, et al

The Significance of Psychosis in BD, Schizophrenia, Bipolar Disord; ePub 2018 May 18; Bowie, et al

Social Cognition Status Effect on Bipolar Disorder, J Affect Disord; ePub 2018 Mar 29; Ospina, et al

Lifetime Anxiety History in the Course of BSDs, Psychiatry Res; ePub 2018 Apr 2; Titone, et al

Serious Mental Illness Linked with Violent Behavior, J Interpers Violence; ePub 2018 Mar 13; Roche, et al