Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Smokers with BD and Quit Rates Examined

Drug Alcohol Depend; 2018 Dec 1; Heffner, et al

Smokers with bipolar disorder (BD) and other affective disorders (ADs) had similar long-term quit rates despite numerous differences in baseline characteristics, a recent study found. Despite being lower than for smokers without mental health conditions (MHCs), long-term quit rates from web-based treatment are promising for smokers with BD as well as other ADs. Participants (n=2,570) were a subsample of those enrolled in a smoking cessation trial comparing 2 web-delivered intervention approaches: acceptance and commitment therapy (ACT) and cognitive behavioral therapy. Those included in this analysis self-reported having BD (n=221), other ADs (n=783) or no major MHCs (n=1,566). Surveys assessed baseline characteristics and self-reported abstinence at 3, 6, and 12-months post-randomization. Treatment utilization was tracked via page views. Researchers found:

  • Smokers with BD were distinct from both AD and no MHC smokers on the majority of baseline characteristics.
  • At 12-months, quit rates were lower for smokers with BD (20%) than no MHCs (29%), but no different than other ADs (20%).
  • Interactions between treatment assignment and diagnostic group were non-significant for cessation outcome.


Heffner JL, Mulla KE, Watson NL, McClure JB, Bricker JB. Smokers with bipolar disorder, other affective disorders, and no mental health conditions: Comparison of baseline characteristics and success at quitting in a large 12-month behavioral intervention randomized trial. Drug Alcohol Depend. 2018;193:35-41. doi:10.1016/j.drugalcdep.2018.08.034.