Clinically significant weight gain (CSWG) predicted neuroprogression in bipolar disorder I (BD-I), and neuroprogression predicted a worse clinical illness course, a recent study found. In 55 early‐stage BD-I patients, researchers measured 1) rates of CSWG, 2) the number of days with mood symptoms, using National Institute of Mental Health’s LifeCharts, and 3) baseline and 12‐month brain volumes, using 3T MRI. They quantified brain volumes using the longitudinal processing stream in FreeSurfer v6.0 and used general linear models for repeated measures to investigate whether CSWG predicted volume loss, adjusting for potentially confounding clinical and treatment variables. They found:
- After correction for multiple comparisons, CSWG in patients predicted greater volume loss in the left orbitofrontal cortex (effect size [ES; Cohen's d] = −1.01), left cingulate gyrus (ES = −1.31), and left middle temporal gyrus (ES = −0.96).
- Middle temporal volume loss predicted more days with depression (β = −0.406).
Bond DJ, Su W, Honer WG, et al. Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective MRI study. [Published online ahead of print November 13, 2018]. Bipolar Disord. doi:10.1111/bdi.12722.