Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Schizophrenia-Spectrum Disorders and Aggression

Schizophrenia Res; ePub 2017 Oct 25; Blanco, et al

As a whole, those with schizophrenia-spectrum disorders (SSD) had higher odds of aggression than those with bipolar disorder (BD), according to a recent study. However, after subdividing these groups, schizophrenia had higher odds of aggression than BD with a recent manic episode and lower odds of aggression than BD with a recent mixed episode. A retrospective study was conducted using data from 3,322 patients who were evaluated at emergency psychiatric settings. The data included demographic information, variables related to aggression towards people or property in the past 6 months, and other factors that could potentially impact the risk of aggression. Researchers found:

  • An initial multivariate regression analysis showed that SSD had 3.1 times the odds of aggression, while BD had 2.2 times the odds of aggression compared to unipolar depression.
  • A second regression analysis including bipolar subtypes showed, using unipolar depression as the reference group, that BD with a recent mixed episode had an odds ratio (OR) of 4.3; schizophrenia, OR of 2.6; and BD with a recent manic episode, OR of 2.2.

Citation:

Blanco EA, Duque LM, Rachamallu V, Yuen E, Kane JM, Gallego JA. Predictors of aggression in 3,322 patients with affective disorders and schizophrenia spectrum disorders evaluated in an emergency department setting. [Published online ahead of print October 25, 2017]. Schizophrenia Res. doi:10.1016/j.schres.2017.10.002.

This Week's Must Reads

Folic Acid Exposure Linked with Psychosis Reduction, JAMA Psychiatry; ePub 2018 Jul 3; Eryilmaz, et al

Increasing Trend of Naloxone Use in the US, Addiction; ePub 2018 Jul 10; Rege, Ngo, et al

Antipsychotic Use Examined Across Wide Age Range, Int J Geriatr Psych; ePub 2018 Jul 8; Jester, et al

FDA Approves New Dosing Formulation for Nuplazid, Acadia Pharmaceuticals Inc. news release; 2018 Jun 29

Midlife Fitness Linked with Lower Depression Risk , JAMA Psychiatry; ePub 2018 Jun 27; Willis, et al

Must Reads in Bipolar Disorder

Bipolar Illness and Multigenerational Transmission, Bipolar Disord; ePub 2018 Jun 21; Post, Altshuler, et al

The Significance of Psychosis in BD, Schizophrenia, Bipolar Disord; ePub 2018 May 18; Bowie, et al

Social Cognition Status Effect on Bipolar Disorder, J Affect Disord; ePub 2018 Mar 29; Ospina, et al

Lifetime Anxiety History in the Course of BSDs, Psychiatry Res; ePub 2018 Apr 2; Titone, et al

Serious Mental Illness Linked with Violent Behavior, J Interpers Violence; ePub 2018 Mar 13; Roche, et al