Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Psychotic Symptoms in BD Linked to Worse Profile

Compr Psychiatry; ePub 2017 Apr 21; Dell’Osso, et al

A recent study indicates an overall worse profile of socio-demographic and certain clinical characteristics associated with the lifetime presence of psychotic symptoms in bipolar patients. This study assessed the lifetime presence of psychotic symptoms and related socio-demographic and clinical features in a large sample of bipolar disorder (BD) patients (n=360), with psychotic symptoms (BDPs, n=207), and without a lifetime history of psychosis (BDNPs, n=153). Researchers found:

  • An overall less favorable socio-demographic profile was observed in BDPs vs BDNPs.
  • In terms of clinical variables, BDPs vs BDNPs had: earlier age at onset (27.7 ± 10.5 vs 30.1 ± 12.3 years), higher rates of BD I diagnosis (95.7% vs 45.8%), more elevated (manic/hypomanic/mixed) polarity of first (55.2% vs 24.4%) and most recent episode (69.8% vs 35.6%), more comorbid alcohol/substance use disorder (38.1% vs 21.9%;), and more lifetime hospitalizations (3.8 ± 6.1 vs 2 ± 3) and involuntary commitments (1 ± 1.9 vs 0.1 ± 0.4).


Dell’Osso B, Camuri G, Cremaschi L, et al. Lifetime presence of psychotic symptoms in bipolar disorder is associated with less favorable socio-demographic and certain clinical features. [Published online ahead of print April 21, 2017]. Compr Psychiatry. doi:10.1016/j.comppsych.2017.04.005.