There are no prognostic differences in risk of psychotic recurrence between the constructs of the various types of brief psychotic episodes, according to a meta-analysis of 82 studies involving 11,133 individuals. Conversely, there appears to be better long-term prognosis of brief psychotic episodes compared with remitted first-episode schizophrenia (FES).
Using participants with FES as a benchmark, investigators looked at the proportion of patients with baseline episodes who had any psychotic recurrence at 6, 12, 24, and 36 or more months of follow-up. They specifically evaluated these episode types:
• Acute and transient psychotic disorder.
• Brief psychotic disorder.
• Brief intermittent psychotic symptoms.
• Brief limited intermittent psychotic symptoms.
Among the results:
• There was no prognostic difference in risk of psychotic recurrence between the different types of episodes at any follow-up.
• Risk of psychotic recurrence was greater in those with FES at 24 months and ≥36 months vs the other 4 groups.
Citation: Fusar-Poli P, Cappucciati M, Bonoldi I, et al. Prognosis of brief psychotic episodes: A meta-analysis. [Published online ahead of print January 13, 2016]. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2015.2313.
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