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Prognosis of Brief Psychotic Episodes

Does recurrence risk differ between types?

There are no prognostic differences in risk of psychotic recurrence between the constructs of the various types of brief psychotic episodes, according to a meta-analysis of 82 studies involving 11,133 individuals. Conversely, there appears to be better long-term prognosis of brief psychotic episodes compared with remitted first-episode schizophrenia (FES).

Using participants with FES as a benchmark, investigators looked at the proportion of patients with baseline episodes who had any psychotic recurrence at 6, 12, 24, and 36 or more months of follow-up. They specifically evaluated these episode types:

• Acute and transient psychotic disorder.

• Brief psychotic disorder.

• Brief intermittent psychotic symptoms.

• Brief limited intermittent psychotic symptoms.

Among the results:

• There was no prognostic difference in risk of psychotic recurrence between the different types of episodes at any follow-up.

• Risk of psychotic recurrence was greater in those with FES at 24 months and ≥36 months vs the other 4 groups.

Citation: Fusar-Poli P, Cappucciati M, Bonoldi I, et al. Prognosis of brief psychotic episodes: A meta-analysis. [Published online ahead of print January 13, 2016]. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2015.2313.