Parental migraine, even in the absence of parental bipolar disorder (BD), is a risk factor for offspring BD, a recent study found. Thus, a genetic link between BD and migraine could potentially explain some of the elevated comorbidity between these disorders. Researchers identified 1,861 cases (aged ≤25 years, 3,643 matched controls), and their parents. They found:
• Parental migraine, controlling for parental BD, was associated with offspring BD diagnosed at age ≥18 years.
• Associations between BD and comorbid migraine persisted following adjustment for parental BD and parental migraine in all subjects, both age groups of BD diagnosis (<18 years, ≥18 years), and both sexes.
• BD, however, shows a stronger association with comorbid migraine than with parental migraine, suggesting that much of the elevated comorbidity is related to non-genetic factors.
Citation: Sucksdorff D, Brown AS, Chudal R, Heinimaa M, Suominen A, Sourander A. Parental and comorbid migraine in individuals with bipolar disorder: A nationwide register study. [Published online ahead of print July 19, 2016]. J Affect Disord. doi:10.1016/j.jad.2016.07.034.