Interventions focused on motor activity and energy may have greater efficacy than current approaches that target depressed mood in adults with bipolar disorder (BD), according to a recent study. This study used a nested case-control design of 242 adults, a subsample of a community-based sample of adults. Probands were recruited by mail from the greater Washington, DC, metropolitan area from January 2005 to June 2013. Data analysis was performed from June 2013 through July 2018. Researchers found:
- Of the total participants, 92 (38.1%) were men and 150 (61.9%) were women, with a mean (SD) age of 48 (16.9) years.
- Among the participants, 54 (22.3%) had BD (25 with BD-I; 29 with BD-II), 91 (37.6%) had major depressive disorder, and 97 (40.1%) were controls with no history of mood disorders.
- A unidirectional association was found between motor activity and subjective mood level (β = –0.018).
- Greater cross-domain reactivity was observed for these associations in people with BD-I.
- Bidirectional associations were observed between motor activity and subjective energy level as well as between motor activity and sleep duration.
Merikangas KR, Swendsen J, Hickie IB, et al. Real-time mobile monitoring of the dynamic associations among motor activity, energy, mood, and sleep in adults with bipolar disorder. [Published online ahead of print December 12, 2018]. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2018.3546.