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Mood Symptoms and Suicidality in Bipolar Disorder

Suicide Life Threat Behav; ePub 2018 Nov 19; Kamali, et al

While dimensions of personality, trauma, and substance use clearly correlated with suicidal behaviors in bipolar disorder (BD), in multivariate models emerging mood symptoms were the most robust predictors of suicidality, a recent study found. These results reinforce the importance and attributable role of mood and anxiety symptoms in evaluating suicidal risk. Mood, personality, and clinical features were assessed in 151 individuals with BD I and 119 healthy controls (HC). Clinical data were collected at baseline and at 2‐year follow‐up. Researchers found:

  • In bivariate analyses, personality measures were significantly different between BD and HC, and between BD based on suicide attempt history.
  • However, in regression analyses, baseline measures of depression, mania, anxiety, trauma, education, and age of BD onset correlated with personality domains, while a history of suicide attempts did not.
  • Logistic regressions showed that prospective depression or mania, and a pattern of mixed mood features and chronicity of illness, along with two Neuroticism facet scores (N4—Self‐Consciousness and N6—Vulnerability) were predictive of suicide ideation (SI) in the 2‐year follow‐up period.

Kamali M, Saunders EFH, Assari S, Ryan KA, Marshall DF, McInnis MG. Mood, dimensional personality, and suicidality in a longitudinal sample of patients with bipolar disorder and controls. [Published online ahead of print November 19, 2018]. Suicide Life Threat Behav. doi:10.1111/sltb.12529.