Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Increased Parkinson’s disease risk seen with bipolar disorder

Key clinical point: Bipolar disorder may be associated with an increased risk of Parkinson’s disease.

Major finding: Individuals with bipolar disorder have a greater than 200% higher risk of Parkinson’s disease.

Study details: A systematic review and meta-analysis of seven studies.

Disclosures: Two authors declared grants and personal fees from the pharmaceutical sector. No other conflicts of interest were reported.


Faustino PR et al. JAMA Neurol. 2019 Oct 14. doi: 10.1001/jamaneurol.2019.3446.