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History of Suicide Attempt and Bipolar Disorder

Association assessed in 2 cohorts

Individuals with bipolar I disorder tended to have a history of suicide attempt in a prospective study of 2 cohorts involving more than 2,000 individuals.

Investigators analyzed data from the NIMH Collaborative Study of Depression, which included 288 patients with bipolar I disorder who were followed for up to 30 years. They also looked at the Bipolar Genomics studies, which involved 1,748 individuals. The trials included 12,667 and 4,529 person-years, respectively.

Suicides/100 person-years were 0.26 and 0.055, respectively. Those with a history of suicide attempt were 2.3 and 2.8 times more likely to commit suicide vs those without history of suicide attempt. (the third highest odds ratio of the risk factors analyzed).

Citation: Coryell W, Kreiner A, Butcher B, et al. Risk factors for suicide in bipolar I disorder in two prospectively studied cohorts. J Affect Disord. 2016;190(13):1-5.