Wrist actigraphy for determination of daytime midpoints is a potential tool to identify objective chronotype in persons with bipolar disorder (BD), which is associated with later sleep and daily activity (evening rather than morning chronotype), a recent study found. Given the ubiquity of accelerometer-based devices (eg, actigraphs/smartphones) worn/used during daytime and tendency to recharge rather than wear at night, researchers assessed chronotype using daytime (rather than sleep) interval midpoints. 61 participants with BD type I (BD-I) or II (BD-II) and 61 healthy controls completed 25–50 days of continuous actigraphy. The Composite Scale of Morningness (CSM) was completed by a subset of this group. They found:
- BD vs controls had delayed daytime midpoint and greater midpoint variability.
- Stratifying by gender and age, females and adolescents with BD had delayed and more variable daytime midpoints vs controls.
- Adults with BD had greater midpoint variability than controls.
- Within-person mean and standard deviations of daytime midpoints were highly correlated with sleep midpoints.
- Daytime midpoint mean was also significantly correlated with the CSM.
Kaufmann CN, Gershon A, Depp CA, Miller S, Zeitzer JM, Ketter TA. Daytime midpoint as a digital biomarker for chronotype in bipolar disorder. J Affect Disord. 2018;241:586-591. doi:10.1016/j.jad.2018.08.032.
This Week's Must Reads
Must Reads in Bipolar Disorder
BD Course Strongly Affected by Comorbid Disorders, J Affect Disord; ePub 2018 Dec 25; Weintraub, et al
Motor Activity, Energy, Mood, Sleep Examined in BD, JAMA Psychiatry; ePub 2018 Dec 12; Merikangas, et al
Differentiating Borderline Personality from BD, Compr Psychiatry; 2019 Jan; Balling, et al
Bipolar Diathesis in Major Depression Disorder , J Affect Disord; ePub 2018 Nov 2; Bennett, et al
Expressed Emotion Among Parents of Youths with BD, Psychiatry Res; 2018 Dec; Millman, Weintraub, et al