Combining psychoeducation and medication appears to be more effective than treatment as usual, according to a randomized clinical trial of 61 young adults aged 18 to 29 years diagnosed with bipolar disorder.
Biological rhythm was assessed with the Biological Rhythm Interview Assessment in Neuropsychiatry. Participants were then randomized to psychoeducation plus medication or medication alone. Although it failed to separate by a marginal difference, the combined intervention seems to be more effective than medication alone with regard to improving depressive symptoms and regulating sleep/social domain at 6 months' follow-up.
The authors noted the importance of their findings, since improvement of depressive symptoms and regulation of sleep and social activities are known to prevent episode onset and thus improve long-term outcomes.
Citation: Cardoso T, Mondin TC, Reyes AN, et al. Biological rhythm and bipolar disorder: Twelve-month follow-up of a randomized clinical trial. J Nerv Ment Dis. 2015;203(10):792-7977.
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