Recent-onset medication-free bipolar disorder is associated with higher triglyceride levels, according to a recent study. These findings are suggestive of early metabolic dysregulation prior to long-term psychotropic medication exposure. Therefore, lower omega-3 polyunsaturated fatty acid (PUFA) levels in individuals with bipolar I disorder represent a potential therapeutic target for additional investigation. Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56). Patients were medication-free at assessment and had no or limited exposure to mood-stabilizer or antipsychotic medications prior to the current admission. Researchers found:
- Following adjustment for demographic variables (ie, age, gender, and parental education), significantly higher fasting triglyceride levels were observed in the bipolar group compared to the healthy group (121.7 mg/dL vs 87.0 mg/dL).
- There were no clear trends for other metabolic indicators, including blood pressure, body mass index, and fasting glucose.
- 19% of the bipolar group and 6% of the healthy group met the criteria for metabolic syndrome.
- The omega-3 index was lower in the bipolar group (3.4% vs 3.9%).
Wulsin LR, Blom TJ, Durling M, et al. Cardiometabolic risks and omega-3 index in recent-onset bipolar I disorder. [Published online ahead of print February 26, 2018]. Bipolar Disord. doi:10.1111/bdi.12633.
This Week's Must Reads
Cognition Impairment a Familial Disposition of MDD, JAMA Psychiatry; ePub 2018 Dec 26; Mackenzie, et al
Cognition in MDD and Aberrant Network Connectivity, J Psychiatr Res; 2019 Mar; Albert, Potter, Boyd, et al
Partner Criticism During Therapy for Recurrent MDD, Behav Res Ther; ePub 2018 Dec 21; Vittengl, et al
Study: Predictions of MDD Are Multifactorial, Depress Anxiety; ePub 2018 Dec 5; van Bronswijk, et al
Linguistic Analysis of Memories of People with MDD, PLoS One; ePub 2018 Nov 26; Himmelstein, et al
Must Reads in Bipolar Disorder
BD Course Strongly Affected by Comorbid Disorders, J Affect Disord; ePub 2018 Dec 25; Weintraub, et al
Differentiating Borderline Personality from BD, Compr Psychiatry; 2019 Jan; Balling, et al
Bipolar Diathesis in Major Depression Disorder , J Affect Disord; ePub 2018 Nov 2; Bennett, et al
Expressed Emotion Among Parents of Youths with BD, Psychiatry Res; 2018 Dec; Millman, Weintraub, et al
Predicting Risk of Conversion from Mania to BD I/II , J Am Acad Child Adolesc Psychiatry; 2018 Oct; Birmaher, et al