Recent-onset medication-free bipolar disorder is associated with higher triglyceride levels, according to a recent study. These findings are suggestive of early metabolic dysregulation prior to long-term psychotropic medication exposure. Therefore, lower omega-3 polyunsaturated fatty acid (PUFA) levels in individuals with bipolar I disorder represent a potential therapeutic target for additional investigation. Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56). Patients were medication-free at assessment and had no or limited exposure to mood-stabilizer or antipsychotic medications prior to the current admission. Researchers found:
- Following adjustment for demographic variables (ie, age, gender, and parental education), significantly higher fasting triglyceride levels were observed in the bipolar group compared to the healthy group (121.7 mg/dL vs 87.0 mg/dL).
- There were no clear trends for other metabolic indicators, including blood pressure, body mass index, and fasting glucose.
- 19% of the bipolar group and 6% of the healthy group met the criteria for metabolic syndrome.
- The omega-3 index was lower in the bipolar group (3.4% vs 3.9%).
Wulsin LR, Blom TJ, Durling M, et al. Cardiometabolic risks and omega-3 index in recent-onset bipolar I disorder. [Published online ahead of print February 26, 2018]. Bipolar Disord. doi:10.1111/bdi.12633.
This Week's Must Reads
Depression in Later Life Intervention is Effective, JAMA Psychiatry; ePub 2018 Nov 7; Dias, et al
Inflammation Associated with Suicide Ideation , J Affect Disord; ePub 2018 Nov 6; Mezuk
Alcohol Involvement, Adolescent Risk-Taking Examined, Addiction; ePub 2018 Nov 6; Ellingson, Corley, et al
Insomnia, Suicide Ideation in Schizophrenia Linked, Sleep; ePub 2018 Nov 8; Miller, Parker, et al
Pornography Consumption in the US Examined, J Sex Res; ePub 2018 Oct 25; Solano, et al
Must Reads in Bipolar Disorder
Effect of Childhood Trauma on Adult Decision Making, J Affect Disord; ePub 2018 Oct 5; Larsen, Ospina, et al
BD and Psychotropic Medication: Impact on Pregnancy, J Affect Disord; ePub 2018 Sep 18; Wisner, et al
Bipolar Illness and Multigenerational Transmission, Bipolar Disord; ePub 2018 Jun 21; Post, Altshuler, et al
The Significance of Psychosis in BD, Schizophrenia, Bipolar Disord; ePub 2018 May 18; Bowie, et al
Social Cognition Status Effect on Bipolar Disorder, J Affect Disord; ePub 2018 Mar 29; Ospina, et al