Recent-onset medication-free bipolar disorder is associated with higher triglyceride levels, according to a recent study. These findings are suggestive of early metabolic dysregulation prior to long-term psychotropic medication exposure. Therefore, lower omega-3 polyunsaturated fatty acid (PUFA) levels in individuals with bipolar I disorder represent a potential therapeutic target for additional investigation. Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56). Patients were medication-free at assessment and had no or limited exposure to mood-stabilizer or antipsychotic medications prior to the current admission. Researchers found:
- Following adjustment for demographic variables (ie, age, gender, and parental education), significantly higher fasting triglyceride levels were observed in the bipolar group compared to the healthy group (121.7 mg/dL vs 87.0 mg/dL).
- There were no clear trends for other metabolic indicators, including blood pressure, body mass index, and fasting glucose.
- 19% of the bipolar group and 6% of the healthy group met the criteria for metabolic syndrome.
- The omega-3 index was lower in the bipolar group (3.4% vs 3.9%).
Wulsin LR, Blom TJ, Durling M, et al. Cardiometabolic risks and omega-3 index in recent-onset bipolar I disorder. [Published online ahead of print February 26, 2018]. Bipolar Disord. doi:10.1111/bdi.12633.
This Week's Must Reads
Inflammatory Diet Linked with Depressive Symptoms, J Affect Disord; ePub 2018 Apr 3; Shivappa, et al
Schizotypes and Social Cognition Task Performance , Psychiatry Res; ePub 2018 Apr 4; Pflum, Gooding
Loss of Control Eating and Metabolic Syndrome, Int J Eat Disord; ePub 2018 Apr 1; Shank, et al
Consanguineous Parents, Psychopathology of Progeny, JAMA Psychiatry; ePub 2018 Apr 4; Maguire, et al
Pornography Use and Relationship Satisfaction, J Sex Res; ePub 2018 Mar 26; Maas, et al
Must Reads in Bipolar Disorder
Social Cognition Status Effect on Bipolar Disorder, J Affect Disord; ePub 2018 Mar 29; Ospina, et al
Lifetime Anxiety History in the Course of BSDs, Psychiatry Res; ePub 2018 Apr 2; Titone, et al
Serious Mental Illness Linked with Violent Behavior, J Interpers Violence; ePub 2018 Mar 13; Roche, et al
BP Disorder Linked with Higher Triglyceride Levels, Bipolar Disord; ePub 2018 Feb 26; Wulsin, et al
Olfactory Processing in Mood Disorders Examined, Bipolar Disord; ePub 2018 Feb 13; Kamath, et al