A family history of illness burden in prior generations was previously related to an earlier age of onset of bipolar illness in adult patients with bipolar disorder (BD) and is now also found to be related to the incidence of multiple psychiatric illnesses in their offspring. This according to a recent study that explored the potential multigenerational conveyance across several disorders of the vulnerability to illness in the offspring of a patient with BD. A total of 968 outpatients (average age 41 years) with bipolar illness filled out a detailed questionnaire about a family history in their parents, grandparents, and offspring of depression, BD, alcohol abuse, substance abuse, suicide attempt, or “other” illness. Researchers found:
- The type of illness seen in both prior generations was associated with the same type of illness in the offspring of a bipolar patient, including depression, BD, alcohol and substance abuse, and “other” illness, but not suicide attempts.
- There was an impact of multiple generations, such that depression in grandparents and/or great‐grandparents increased the risk of depression in the offspring from 12.6% to 41.4%.
Post RM, Altshuler LL, Kupka, et al. Multigenerational transmission of liability to psychiatric illness in offspring of parents with bipolar disorder. [Published online ahead of print June 21, 2018]. Bipolar Disord. doi:10.1111/bdi.12668.
This Week's Must Reads
Schizophrenia and Cardioprotective Treatment for MI, JAMA Psychiatry; ePub 2018 Oct 24; Kugathasan, et al
Schizophrenia and Goal-Directed Planning Examined, Schizophr Res; ePub 2018 Nov 22; Siddiqui, et al
Patient-Reported Outcomes for Weight Management, J Behav Health Serv Res; ePub 2018 Nov 21; Young, et al
Schizophrenia Linked with Aberrant Response to EBV, Schizophr Bull; ePub 2018 Nov 20; Dickerson, et al
Plasticity-Related Aberrations in Schizophrenia, Schizophr Res; ePub 2018 Nov 12; Smith, et al
Must Reads in Bipolar Disorder
Reduced Lateral OFC Volume and Suicidality in BD, Bipolar Disord; ePub 2018 Nov 24; Huber, et al
Subthreshold Pediatric BD Linked with Suicide Risk, Bipolar Disord; ePub 2018 Nov 27; Vaudreuil, et al
Mood Symptoms and Suicidality in Bipolar Disorder, Suicide Life Threat Behav; ePub 2018 Nov 19; Kamali, et al
Smokers with BD and Quit Rates Examined, Drug Alcohol Depend; 2018 Dec 1; Heffner, et al
Determining Objective Chronotype in Persons with BD, J Affect Disord; 2018 Dec; Kaufmann, et al