Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Bipolar Disorder Linked with More Somatic Symptoms

J Affect Disord; ePub 2016 Jun 14; Edgcomb, Tseng, et al

Persons with bipolar spectrum disorders (BSD) suffer from somatic symptoms at a rate nearly double that of the general population, a rate similar to persons with unipolar depression (UPD), a recent study found. Researchers conducted a systematic review and meta-analysis of empirical studies published between 1980 and 2015, comparing the odds for somatic symptoms in BSD with UPD and general population or mixed psychiatric controls. Out of 2,634 studies, 23 were eligible for inclusion, yielding a total of 106,785 patients. They found:

• The estimated prevalence of somatic symptoms in BSD was 47.8%.

• The estimated prevalence of BSD in persons with somatic symptoms was 1.4%.

• Persons with BSD had a higher prevalence of somatic symptoms compared with population or mixed psychiatric controls.

• Persons with BSD had a similar prevalence of somatic symptoms compared with UPD controls.

Citation: Edgcomb JB, Tseng CH, Kerner B. Medically unexplained somatic symptoms and bipolar spectrum disorders: A systematic review of meta-analysis. [Published online ahead of print June 14, 2016]. J Affect Disord. doi:10.1016./j.jad.2016.06.029.

This Week's Must Reads

Schizophrenia and Cardioprotective Treatment for MI, JAMA Psychiatry; ePub 2018 Oct 24; Kugathasan, et al

Schizophrenia and Goal-Directed Planning Examined, Schizophr Res; ePub 2018 Nov 22; Siddiqui, et al

Patient-Reported Outcomes for Weight Management, J Behav Health Serv Res; ePub 2018 Nov 21; Young, et al

Schizophrenia Linked with Aberrant Response to EBV, Schizophr Bull; ePub 2018 Nov 20; Dickerson, et al

Plasticity-Related Aberrations in Schizophrenia, Schizophr Res; ePub 2018 Nov 12; Smith, et al

Must Reads in Bipolar Disorder

Reduced Lateral OFC Volume and Suicidality in BD, Bipolar Disord; ePub 2018 Nov 24; Huber, et al

Subthreshold Pediatric BD Linked with Suicide Risk, Bipolar Disord; ePub 2018 Nov 27; Vaudreuil, et al

Mood Symptoms and Suicidality in Bipolar Disorder, Suicide Life Threat Behav; ePub 2018 Nov 19; Kamali, et al

Smokers with BD and Quit Rates Examined, Drug Alcohol Depend; 2018 Dec 1; Heffner, et al

Determining Objective Chronotype in Persons with BD, J Affect Disord; 2018 Dec; Kaufmann, et al