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Bipolar Diathesis in Major Depression Disorder

J Affect Disord; ePub 2018 Nov 2; Bennett, et al

Bipolar diathesis in major depressive disorder (MDD) is not a safety concern but may lead to somewhat lower remission rates when considering transcranial magnetic stimulation (TMS) treatment, according to a recent study. Researchers conducted a retrospective chart review of MDD patients (n=105) treated with TMS. Bipolar disorder (BD) diathesis was defined by responses to a modified version of the Mood Disorder Questionnaire and family history. They found:

  • TMS response rates for the group with BD diathesis and the group without were equivalent using 2 self-report depression severity scales.
  • Remission rate was significantly lower for the bipolar soft signs group (13.5% vs 30.2%) on 1 scale.
  • This result does not hold when corrected for multiple comparisons.
  • A switch to mania was not observed.


Bennett E, Almeida JRC, Carpenter LL. Do bipolar disorder soft signs impact outcomes following transcranial magnetic stimulation (TMS) therapy for depression? [Published online ahead of print November 2, 2018]. J Affect Disord. doi:10.1016/j.jad.2018.10.367.