4 interventions were found to have strong evidence of effectiveness in addressing key medical conditions and health-risk behaviors in those with severe mental illness, according to a comprehensive review of 108 studies.
Investigators selected randomized controlled trials and observational studies testing a number of interventions among individuals with schizophrenia and bipolar disorder. Of the 108 studies selected, 80 addressed overweight/obesity. They ranked the quality of the evidence and intervention effectiveness.
Evidence was ranked high for:
• Metformin and behavioral intervention effects on weight loss.
• Bupropion and varenicline intervention effects on reduced tobacco smoking.
Evidence was ranked low for most other interventions.
Citation: McGinty E, Baller J, Azrin S, Juliano-Bult D, Daumit G. Interventions to address medical conditions and health-risk behaviors among persons with serious mental illness: A comprehensive review. Schizophr Bull. 2016;42(1):96-124.
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Family Involvement in Veterans with Schizophrenia, Psychiatr Rehabil J; ePub 2019 Mar 28; Cohen, et al
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Continuous Exercise & CI in Schizophrenia, Front Psychiatry; ePub 2019 Mar 13; Herbsleb, et al
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BD Course Strongly Affected by Comorbid Disorders, J Affect Disord; ePub 2018 Dec 25; Weintraub, et al
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Differentiating Borderline Personality from BD, Compr Psychiatry; 2019 Jan; Balling, et al
Bipolar Diathesis in Major Depression Disorder , J Affect Disord; ePub 2018 Nov 2; Bennett, et al
Expressed Emotion Among Parents of Youths with BD, Psychiatry Res; 2018 Dec; Millman, Weintraub, et al