Clinical Edge

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Addressing Health-Risk Behaviors in Mentally Ill

Which interventions have the strongest evidence?

4 interventions were found to have strong evidence of effectiveness in addressing key medical conditions and health-risk behaviors in those with severe mental illness, according to a comprehensive review of 108 studies.

Investigators selected randomized controlled trials and observational studies testing a number of interventions among individuals with schizophrenia and bipolar disorder. Of the 108 studies selected, 80 addressed overweight/obesity. They ranked the quality of the evidence and intervention effectiveness.

Evidence was ranked high for:

• Metformin and behavioral intervention effects on weight loss.

• Bupropion and varenicline intervention effects on reduced tobacco smoking.

Evidence was ranked low for most other interventions.

Citation: McGinty E, Baller J, Azrin S, Juliano-Bult D, Daumit G. Interventions to address medical conditions and health-risk behaviors among persons with serious mental illness: A comprehensive review. Schizophr Bull. 2016;42(1):96-124.

This Week's Must Reads

Family Involvement in Veterans with Schizophrenia, Psychiatr Rehabil J; ePub 2019 Mar 28; Cohen, et al

Cognitive Training Program in Schizophrenia, Schizophr Res; ePub 2019 Mar 28; Mahncke, et al

Continuous Exercise & CI in Schizophrenia, Front Psychiatry; ePub 2019 Mar 13; Herbsleb, et al

MHC Risk Variants in Cortical Thickness, Brain Behav; ePub 2019 Mar 28; Tao, et al

Disclosing the Diagnosis of Schizophrenia, Int J Soc Psychiatry; ePub 2019 Mar 27; Setti, et al

Must Reads in Bipolar Disorder

BD Course Strongly Affected by Comorbid Disorders, J Affect Disord; ePub 2018 Dec 25; Weintraub, et al

Motor Activity, Energy, Mood, Sleep Examined in BD, JAMA Psychiatry; ePub 2018 Dec 12; Merikangas, et al

Differentiating Borderline Personality from BD, Compr Psychiatry; 2019 Jan; Balling, et al

Bipolar Diathesis in Major Depression Disorder , J Affect Disord; ePub 2018 Nov 2; Bennett, et al

Expressed Emotion Among Parents of Youths with BD, Psychiatry Res; 2018 Dec; Millman, Weintraub, et al