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Study Examines “Depression Paradox” with CV Events

Psychiatry Res; ePub 2018 Mar 20; Pino, Zuo, et al

Results of a recent study are suggestive of potentially underdiagnosed mental health issues surrounding major cardiovascular events, and indeed, chronic disease as a whole. To the researchers’ knowledge, this is the first study to document and examine the “depression paradox” among a population of cardiac patients. Using data from the Nationwide Inpatient Sample (NIS) from the years 2004 to 2013, they assessed whether a clinical co-diagnosis of depression and/or anxiety decreases the likelihood of revascularization among ST-elevation myocardial infarction (STEMI) hospitalizations. They found:

  • Paradoxically, the odds of in-hospital mortality were lower among STEMI hospitalizations with a clinical co-diagnosis of depression and/or anxiety as compared to those without.
  • It was further discovered that clinical diagnoses of depression and/or anxiety were less prevalent among revascularized as compared to non-revascularized STEMI hospitalizations.
  • However, the percentage of clinical diagnoses of depression and/or anxiety among STEMI hospitalizations increased at a similar rate over a 10-year period irrespective of revascularization status.


Pino EC, Zuo Y, Borba CPC, Henderson DC, Kalesan B. Clinical depression and anxiety among ST-elevation myocardial infarction hospitalizations: Results from Nationwide Inpatient Sample 2004-2013. [Published online ahead of print March 20, 2018]. Psychiatry Res. doi:10.1016/j.psychres.2018.03.025.

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