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Inflammation and Stress Pathology Associated

J Psych Res; ePub 2017 Jan 14; Rosen, et al

In a recent large study of the relationship between C-reactive protein (CRP) and posttraumatic stress pathology, researchers demonstrated an association between systemic inflammation and stress pathology (PTSD; trending with depression), which remained after adjusting for potentially confounding variables. These results contribute to research findings suggesting a salient relationship between inflammation and posttraumatic stress pathology. Researchers analyzed a large naturalistic cohort sharing a discrete physical and mental health trauma from the destruction of the World Trade Center (WTC) towers on September 11, 2001 (n=641). They found:

  • CRP was positively associated with PTSD severity, trending toward association with depression, but not with anxiety.
  • CRP was positively associated with re-experiencing and avoidance symptom clusters, and trended toward associations with negative cognitions/mood and arousal.


Rosen R, Levy-Carrick N, Reibman J, et al. Elevated C-reactive protein and posttraumatic stress pathology among survivors of the 9/11 World Trade Center attacks. [Published online ahead of print January 14, 2017]. J Psych Res. doi:10.1016/j.jpsychires.2017.01.007.