Clinical Edge

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Higher risk of bipolar disorder, depression, anxiety found with autism

Key clinical point: Individuals with autism spectrum disorder have significantly higher risks of bipolar disorder, depression, and anxiety.

Major finding: The risk of bipolar disorder is ninefold higher among individuals with autism spectrum disorder.

Study details: Population-based cohort study in 1,014 individuals with autism spectrum disorder and 2,028 matched controls.

Disclosures: The study was funded by the National Institutes of Health and the U.S. Public Health Service. No conflicts of interest were disclosed.


Kirsch A et al. JAMA Pediatr. 2019 Dec 2. doi: 10.1001/jamapediatrics.2019.4368.