Non-social comorbid anxiety disorders may reduce the efficacy of acute-phase cognitive therapy (CT) for major depressive disorder (MDD) by diminishing both short- and longer term outcomes relative to depressed patients without comorbid anxiety disorders. This according to a recent study that compared CT outcomes among adults with MDD plus social, other, or no comorbid anxiety disorders. Outpatients with recurrent MDD (n=523, including 87 with social and 110 with other comorbid anxiety disorders) received acute-phase CT. Higher risk responders (n=241 with partial or unstable response) were randomized to 8 months of continuation treatment (CT or clinical management plus medication or pill placebo), followed by 24 months of assessment. Lower risk responders (n=49) were assessed for 32 months without additional research treatment. Depression, anxiety symptoms, and social avoidance were measured repeatedly. Researchers found:
- Other (non-social), but not social, anxiety disorders predicted elevated depression and anxiety symptoms throughout and after acute-phase CT.
- Social, but not other, anxiety disorders predicted greater reduction in depressive symptoms during acute-phase CT and elevated social avoidance during and after acute-phase CT.
Vittengl JR, Clark LA, Smits JAJ, Thase ME, Jarrett RB. Do comorbid social and other anxiety disorders predict outcomes during and after cognitive therapy for depression? [Published online ahead of print August 25, 2018]. J Affect Disord. doi:10.1016/j.jad.2018.08.053.
This Week's Must Reads
Family Involvement in Veterans with Schizophrenia, Psychiatr Rehabil J; ePub 2019 Mar 28; Cohen, et al
Cognitive Training Program in Schizophrenia, Schizophr Res; ePub 2019 Mar 28; Mahncke, et al
Continuous Exercise & CI in Schizophrenia, Front Psychiatry; ePub 2019 Mar 13; Herbsleb, et al
MHC Risk Variants in Cortical Thickness, Brain Behav; ePub 2019 Mar 28; Tao, et al
Disclosing the Diagnosis of Schizophrenia, Int J Soc Psychiatry; ePub 2019 Mar 27; Setti, et al
Must Reads in Anxiety Disorders
Predictors of Response to sTMS in Patients with MDD, Depress Anxiety; ePub 2018 Nov 27; Philip, et al
Pediatric Anxiety Diagnoses and Hospitalizations, Depress Anxiety; ePub 2018 Oct 24; Bushnell, et al
Anxious Distress Common in Depressed Patients, Depress Anxiety; ePub 2018 Oct 12; Zimmerman, et al
Comorbid Anxiety Disorders Effect on MDD Therapy, J Affect Disord; ePub 2018 Aug 25; Vittengl, et al