Anxiety is common in bipolar disorder (BD) and lifetime and current anxiety are associated with hastened bipolar depressive recurrence, a recent study found. Stanford BD Clinic outpatients enrolled during 2000–2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation and followed with the STEP-BD Clinical Monitoring Form while receiving naturalistic treatment for up to 2 years. Researchers found:
- Among 105 currently recovered patients, lifetime anxiety disorder was significantly associated with 10/27 (37.0%) demographic/other unfavorable illness characteristics/current mood symptoms/current psychotropics, hastened depressive recurrence (driven by earlier onset age), and a significantly (>2-fold) higher Kaplan-Meier estimated depressive recurrence rate.
- Current anxiety symptoms were significantly associated with 10/27 (37.0%) demographic/other unfavorable illness characteristics/current mood symptoms/current psychotropics and hastened depressive recurrence (driven by lifetime anxiety disorder), but only a numerically higher Kaplan-Meier estimated depressive recurrence rate.
- In contrast, among 153 currently depressed patients, lifetime anxiety disorder/current anxiety symptoms were not significantly associated with time to depressive recovery or depressive recovery rate.
Shah S, Kim JP, Park DY, et al. Lifetime anxiety disorder and current anxiety symptoms associated with hastened depressive recurrence in bipolar disorder. [Published online ahead of print May 8, 2017]. J Affect Disord. doi:10.1016/j.jad.2017.05.007.
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Predictors of Response to sTMS in Patients with MDD, Depress Anxiety; ePub 2018 Nov 27; Philip, et al
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