Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Depressed Elders Exhibit Greater Cognitive Decline

Am J Geriatr Psychiatry; ePub 2017 Mar 27; Riddle, et al

Consistent with past studies, depressed elders exhibit greater cognitive decline than nondepressed subjects, particularly individuals with early depression onset, according to a recent study. 273 depressed and 164 never-depressed community dwelling elders aged ≥60 years were followed on average for >5 years. Participants completed annual neuropsychological testing and neuropsychological measures were converted to z-scores derived from the baseline performance of all participants. Researchers found:

  • Depressed participants exhibited poorer performance at baseline and greater subsequent decline in all domains.
  • Early-onset depressed individuals exhibited a greater decline in all domains than the late-onset or nondepressed groups.
  • For remission, remitters and nonremitters at both 3- and 12-months exhibited greater decline in episodic memory and attention-working memory than nondepressed subjects.
  • 3-month remitters also exhibited a greater decline in verbal fluency and executive function, while 12-month nonremitters exhibited greater decline in executive function than other groups.


Riddle M, Potter GG, McQuoid DR, Steffens DC, Beyer JL, Taylor WD. Longitudinal cognitive outcomes of clinical phenotypes of late-life depression. [Published online ahead of print March 27, 2017]. Am J Geriatr Psychiatry. doi:10.1016/j.jagp.2017.03.016.

This Week's Must Reads

Family Involvement in Veterans with Schizophrenia, Psychiatr Rehabil J; ePub 2019 Mar 28; Cohen, et al

Cognitive Training Program in Schizophrenia, Schizophr Res; ePub 2019 Mar 28; Mahncke, et al

Continuous Exercise & CI in Schizophrenia, Front Psychiatry; ePub 2019 Mar 13; Herbsleb, et al

MHC Risk Variants in Cortical Thickness, Brain Behav; ePub 2019 Mar 28; Tao, et al

Disclosing the Diagnosis of Schizophrenia, Int J Soc Psychiatry; ePub 2019 Mar 27; Setti, et al

Must Reads in Alzheimer's & Cognition

Adult ASD and Social/Nonsocial Cognitive Impairment, JAMA Psychiatry; ePub 2019 Jan 2; Velikonja, et al

Post-Bereavement Adjustment in Caregivers Examined, Am J Geriatr Psychiatry; ePub 2018 Nov 2; Stahl, et al

Cognitive Deterioration in Schizophrenia Examined , JAMA Psychiatry; ePub 2018 Oct 3; Niendam, et al

Widowhood a Risk Factor for Cognitive Decline, Am J Geriatr Psychiatry; ePub 2018 Mar 26; Shin, et al