Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Blood pressure lowering lessens risk of dementia, cognitive decline

Key clinical point: A statistically significant association was uncovered between lowering blood pressure and a lower risk of dementia, cognitive impairment, and cognitive decline.

Major finding: Blood pressure lowering via antihypertensive agents compared with control was associated with a reduction in dementia or cognitive impairment (7.0% vs. 7.5% over a mean trial follow-up of 4.1 years; OR, 0.93; ARR, 0.39%).

Study details: A meta-analysis of 14 eligible randomized clinical trials with more than 90,000 participants.

Disclosures: Three authors reported receiving grants or personal fees from the Wellcome Trust and the Health Research Board, the Chief Scientist Office, and Bayer AG, respectively.


Hughes D et al. JAMA. 2020 May 19. doi: 10.1001/jama.2020.4249.