A mechanism related to antidepressant use may reduce the hazard of eventual Alzheimer disease (AD), according to a recent study. Furthermore, the findings reinforce the association between depression, apolipoprotein E (APOE) ε4, and AD diagnosis. Utilizing data from the National Alzheimer's Coordinating Center, researchers examined evaluations of 11,443 cognitively intact participants. Survival analysis was used to explore relationships between depression, apolipoprotein E, AD diagnosis, and antidepressant use. They found:
- An analytical sample of 8,732 participants with normal cognition was examined.
- Among users of antidepressant medication, the hazard, in most cases, was no longer statistically significant.
- 1 generic medication showed protective benefits for users.
- In addition, there was a statistically significant relationship between recent depression (n=2,083), lifetime depression (n=2,068), and ε4 carrier status (n=2,470) and AD development.
Burke SL, Maramaldi P, Cadet T, Kukull W. Decreasing hazards of Alzheimer's disease with the use of antidepressants: Mitigating the risk of depression and apolipoprotein E. [Published online ahead of print May 31, 2017]. Int J Geriatr Psychiatry. doi:10.1002/gps.4709.
This Week's Must Reads
Early-Life Stress Linked with Cytomegalovirus in MDD , JAMA Psychiatry; ePub 2019 Mar 6; Ford, et al
Collaborative Intervention for Obesity, Depression , JAMA; 2019 Mar 5; Ma, Goldman Rosas, Lv, et al
Body Weight Predicts Risk for Depressive Symptoms , J Affect Disord; ePub 2019 Mar 5; Vittengl
Slow-Wave Activity and Mood Disturbance in MDD, Psychol Med; 2019 Mar; Goldschmied, et al
Marijuana Use in MDD May Be Contraindicated, Cogn Affect Behav Neurosci; ePub 2019 Feb 26; Radoman, et al
Must Reads in Alzheimer's & Cognition
Adult ASD and Social/Nonsocial Cognitive Impairment, JAMA Psychiatry; ePub 2019 Jan 2; Velikonja, et al
Post-Bereavement Adjustment in Caregivers Examined, Am J Geriatr Psychiatry; ePub 2018 Nov 2; Stahl, et al
Cognitive Deterioration in Schizophrenia Examined , JAMA Psychiatry; ePub 2018 Oct 3; Niendam, et al
Widowhood a Risk Factor for Cognitive Decline, Am J Geriatr Psychiatry; ePub 2018 Mar 26; Shin, et al
Caregivers of PLWDs at Risk for Sleep Disturbances, Am J Geriatr Psych; ePub 2018 Feb 4; Polenick, et al