Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

MDEs Increasing for Female Juvenile Offenders

Compr Psychiatry; ePub 2017 Sep 12; Holzer, et al

The prevalence of past year major depressive episodes (MDEs) is increasing for female juvenile offenders, highlighting a need for improved efforts to target these populations for prevention and treatment, a recent study found. Data were collected between 2005 and 2014 as part of the National Survey on Drug Use and Health (NSDUH). Participants included 171,118 youth aged 12–17 (159,449 non-offenders and 11,669 offenders). The primary variable of interest was self-reported past year MDE. Researchers found:

  • The prevalence of MDEs among female youth increased for both offender and non-offender groups: from 24.4% to 33.0% for the offenders and from 12.4% to 16.7% for the non-offenders.
  • No significant trend changes were observed among male youth.
  • In both male and female juvenile offenders, MDEs were associated with increased risk of illicit drug use (males OR=1.61; females OR=1.83).
  • Additional correlates include alcohol use among male offenders (OR = 1.36), and binge drinking in female offenders (OR=1.24).


Holzer KJ, Oh S, Salas-Wright CP, Vaughn MG, Landess J. Gender differences in the trends and correlates of major depressive episodes among juvenile offenders in the United States. [Published online ahead of print September 12, 2017]. Compr Psychiatry. doi:10.1016/j.comppsych.2017.09.005.

This Week's Must Reads

Folic Acid Exposure Linked with Psychosis Reduction, JAMA Psychiatry; ePub 2018 Jul 3; Eryilmaz, et al

Increasing Trend of Naloxone Use in the US, Addiction; ePub 2018 Jul 10; Rege, Ngo, et al

Antipsychotic Use Examined Across Wide Age Range, Int J Geriatr Psych; ePub 2018 Jul 8; Jester, et al

FDA Approves New Dosing Formulation for Nuplazid, Acadia Pharmaceuticals Inc. news release; 2018 Jun 29

Midlife Fitness Linked with Lower Depression Risk , JAMA Psychiatry; ePub 2018 Jun 27; Willis, et al

Must Reads in Addiction Medicine

Increasing Trend of Naloxone Use in the US, Addiction; ePub 2018 Jul 10; Rege, Ngo, et al

Positive/Negative Affect in Cocaine Use Disorder, Am J Addictions; ePub 2018 Jun 20; Decker, et al

Do Very Low-Nicotine Cigarettes Aid Abstinence?, JAMA Psychiatry; ePub 2018 Jun 14; Shiffman, et al

FDA Approves Generic Versions of Suboxone , FDA Web site; 2018 Jun 14

Mixed Review for Facebook Smoking Intervention, Addiction; ePub 2018 May 24; Ramo, Thrul, et al