Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Childhood Cancer Survivors and Alcohol Consumption

Addiction; ePub 2018 Sep 8; Brinkman, et al

Drinking initiation during adolescence is associated with modest increased risk for memory impairment and emotional distress in adult survivors of childhood cancer, according to a recent study. Researchers used data from the Childhood Cancer Survivor Study (CCSS), a 26‐center study of >5-year survivors of childhood cancer diagnosed at <21 years between 1970 and 1986 in the US and Canada. 4,484 adult survivors of childhood cancer (mean [SD] age at evaluation = 34.8 [6.1] years; time from diagnosis = 24.8 [4.4] years) and 1,706 sibling controls completed surveys reporting on alcohol use, neurocognitive impairment, and emotional distress. They found:

  • After adjustment for childhood cancer treatment exposures, including cranial radiation therapy, drinking initiation prior to age 18 years was associated with 30% increased risk of subsequent memory problems (Risk Ratio [RR]=1.3).
  • Younger age at drinking initiation was associated with future risk of depression (RR=1.3), anxiety (RR=1.6), and somatization (RR=1.2).
  • Persistent heavy/risky drinking was associated with 80% increased risk of persistent psychological distress (RR=1.8).


Brinkman TM, Lown EA, Li C, et al. Alcohol consumption behaviors and neurocognitive dysfunction and emotional distress in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. [Published online ahead of print September 8, 2018]. Addiction. doi:10.1111/add.14439.

This Week's Must Reads

Schizophrenia and Cardioprotective Treatment for MI, JAMA Psychiatry; ePub 2018 Oct 24; Kugathasan, et al

Schizophrenia and Goal-Directed Planning Examined, Schizophr Res; ePub 2018 Nov 22; Siddiqui, et al

Patient-Reported Outcomes for Weight Management, J Behav Health Serv Res; ePub 2018 Nov 21; Young, et al

Schizophrenia Linked with Aberrant Response to EBV, Schizophr Bull; ePub 2018 Nov 20; Dickerson, et al

Plasticity-Related Aberrations in Schizophrenia, Schizophr Res; ePub 2018 Nov 12; Smith, et al

Must Reads in Addiction Medicine

First Cannabis Use and Prevalence of Use Examined, Addiction; ePub 2018 Nov 26; Han, Compton, et al

Smoking Cessation and Serious Mental Illness, Drug Alcohol Depend; 2018 Jan; Hammett, et al

Electronic Nicotine System Use and Mental Health, Addiction; ePub 2018 Oct 6; Spears, et al

Alcohol Involvement, Adolescent Risk-Taking Examined, Addiction; ePub 2018 Nov 6; Ellingson, Corley, et al

Prescription Opioid Misuse Among College Students, Am J Addictions; ePub 2018 Oct 17; Harries, et al