Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Organ Transplants Carry Risk of Several Cancers

Pediatrics; 2017 May; Yanik, et al

Children who receive organ transplants are far more likely to develop many types of cancer, according to a US transplant registry that was linked to 16 cancer registries. The investigation revealed the following results:

  • 392 cancers were diagnosed among nearly 18,000 children who had received solid organ transplantation.
  • The standardized incidence ratio (SIR) for non-Hodgkin’s lymphoma was significantly increased when compared to the general public.
  • Other cancers that occurred more frequently among transplant recipients included leukemia, myeloma, and cancers of the liver, ovaries, and testes.


Yanik EL, Smith JM, Shiels MS, et al. Cancer risk after pediatric solid organ transplantation. Pediatrics. 2017;139:e20163893. doi:10.1542/peds.2016-3893.

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