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Truncal-to-Leg Ratio and Cardiometabolic Disease

Pediatr Obes; ePub 2019 Jan 25; Cioffi, et al

In a cohort of adolescents, truncal‐to‐leg fat ratio (TLR) was associated with several risk factors independent of body mass index (BMI) z‐score, although some findings were sex or race/ethnicity specific. Therefore, according to this recent study, body fat distribution may be an important determinant of future cardiometabolic (CMD) risk factors. Data were from 3,810 adolescents (12‐19 years old) in the National Health and Examination Survey (NHANES) 2003‐2006. Body fat was assessed by dual‐energy X‐ray absorptiometry, and CMD risk factors were determined by blood samples and physical examination. Linear and logistic regressions adjusted for BMI z‐score and other covariates were used to examine associations of TLR with CMD risk factors as continuous and dichotomized outcomes, respectively. Researchers found:

  • Adolescents who were Mexican American, who have lower income, and with obesity had the highest mean TLR.
  • In linear regression, increasing TLR was associated positively with homeostasis model assessment of insulin resistance (HOMA‐IR), triglycerides, total cholesterol, systolic blood pressure (BP), c‐reactive protein, and alanine aminotransferase (ALT), and negatively with high‐density lipoprotein (HDL) cholesterol in both sexes.
  • TLR was also associated with diastolic BP in boys and low‐density lipoprotein cholesterol in girls.


Cioffi CE, Alvarez JA, Welsh JA, Vos MB. Truncal‐to‐leg fat ratio and cardiometabolic disease risk factors in US adolescents: NHANES 2003‐2006. [Published online ahead of print January 25, 2019]. Pediatr Obes. doi:10.1111/ijpo.12509.

Must Reads in Obesity

Breakfast in the Classroom Initiative and Obesity, JAMA Pediatrics; ePub 2019 Feb 25; Polonsky, et al

Predictors of Victimization of Overweight Youth, Pediatr Obes; ePub 2019 Feb 14; Nabors, et al

Truncal-to-Leg Ratio and Cardiometabolic Disease, Pediatr Obes; ePub 2019 Jan 25; Cioffi, et al

NAFLD Prevalent in Children with Obesity, J Pediatr; ePub 2018 Dec 14; Yu, et al

Prevalence of Obesity, MetS by Geographic Region, Pediatr Obes; ePub 2018 Dec 4; DeBoer, et al