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Risk Factors for Siblings of Children with ASD, ADHD

JAMA Pediatrics; ePub 2018 Dec 10; Miller, et al

Later-born siblings of children with autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD) appear to be at elevated risk for the same disorder, but also of being diagnosed with the other disorder, a recent study found. Using data extracted from medical records of 2 large health care systems in the US, estimates of recurrence risk and cross-aggregation in later-born siblings of children with ADHD or ASD were compared with later-born siblings of children without these diagnoses. Researchers found:

  • A total of 15,175 later-born siblings were classified by familial risk status based on the older child’s diagnostic status: ADHD risk (n=730; male [51.92%]), ASD risk (n=158; male [48.10%]), and no known risk (n= 14,287; male [50.73%]).
  • Compared with later-born siblings of children without ADHD or ASD, later-born siblings of children with ASD were more likely to be diagnosed with ASD or ADHD in the absence of ASD.
  • Compared with later-born siblings of children without a diagnosis, later-born siblings of children with ADHD were more likely to be diagnosed with ADHD or ASD in the absence of ADHD.

Citation:

Miller M, Musser ED, Young GS, Olson B, Steiner RD, Nigg JT. Sibling recurrence risk and cross-aggregation of attention-deficit/hyperactivity disorder and autism spectrum disorder. [Published online ahead of print December 10, 2018]. JAMA Pediatrics. doi:10.1001/jamapediatrics.2018.4076.