Later-born siblings of children with autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD) appear to be at elevated risk for the same disorder, but also of being diagnosed with the other disorder, a recent study found. Using data extracted from medical records of 2 large health care systems in the US, estimates of recurrence risk and cross-aggregation in later-born siblings of children with ADHD or ASD were compared with later-born siblings of children without these diagnoses. Researchers found:
- A total of 15,175 later-born siblings were classified by familial risk status based on the older child’s diagnostic status: ADHD risk (n=730; male [51.92%]), ASD risk (n=158; male [48.10%]), and no known risk (n= 14,287; male [50.73%]).
- Compared with later-born siblings of children without ADHD or ASD, later-born siblings of children with ASD were more likely to be diagnosed with ASD or ADHD in the absence of ASD.
- Compared with later-born siblings of children without a diagnosis, later-born siblings of children with ADHD were more likely to be diagnosed with ADHD or ASD in the absence of ADHD.
Miller M, Musser ED, Young GS, Olson B, Steiner RD, Nigg JT. Sibling recurrence risk and cross-aggregation of attention-deficit/hyperactivity disorder and autism spectrum disorder. [Published online ahead of print December 10, 2018]. JAMA Pediatrics. doi:10.1001/jamapediatrics.2018.4076.
Must Reads in Mental Health
FDA Approves Adhansia XR for ADHD, Adlon Therapeutics news release; 2019 Mar 1
Predictors of Victimization of Overweight Youth, Pediatr Obes; ePub 2019 Feb 14; Nabors, et al