Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Residential Lead Interventions’ Effect on Children

JAMA Pediatrics; ePub 2018 Aug 27; Braun, et al

Residential lead exposures, as well as blood lead concentrations in non-Hispanic black children, were reduced through a comprehensive lead-hazard intervention without elevating the lead body burden, according to a recent, randomized clinical trial of pregnant women and their children. This decrease, however, did not result in substantive neurobehavioral improvements in children. Pregnant women attending 1 of 9 prenatal care clinics were recruited. Of 1,263 eligible women, 468 (37.0%) agreed to participate and 355 women (75.8%) were randomized in this intention-to-treat analysis. Participants were randomly assigned to receive 1 of 2 interventions designed to reduce residential lead or injury hazards. Follow-up on children took place at 1, 2, 3, 4, 5, and 8 years of age. Researchers found:

  • The intervention did not statistically significantly reduce childhood blood lead concentrations.
  • Neurobehavioral test scores were not statistically different between children in the intervention group than those in the control group except for a reduction in anxiety scores in the intervention group.

Braun JM, Hornung R, Chen A, et al. Effect of residential lead-hazard interventions on childhood blood lead concentrations and neurobehavioral outcomes. A randomized clinical trial. [Published online ahead of print August 27, 2018]. JAMA Pediatrics. doi:10.1001/jamapediatrics.2018.2382.

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