Clinical Edge

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Next-generation sequencing test detects pathogens with high sensitivity

Key clinical point: A next-generation sequencing test for pathogen detection demonstrated higher sensitivity than conventional testing methods in a cohort of pediatric patients.

Major finding: The Karius test detected pathogens with 92% sensitivity, compared with 64% sensitivity for all conventional testing methods combined (P less than .01).

Study details: A retrospective analysis of 100 test results in 79 pediatric patients.

Disclosures: The researchers did not receive any funding for this study, but they were previously involved in a study funded by Karius, the company that commercialized the test.


Rossoff J et al. ASPHO 2019, Abstract 439.