Clinical Edge

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Ketoacidosis is on the rise in children with type 1 diabetes

Key clinical point: Diabetic ketoacidosis is a serious complication of type 1 diabetes that can be present in children at diagnosis.

Major finding: As many as 40%-60% of children have DKA at the time of being diagnosed with type 1 disease.

Study details: Three separate studies: a single-center analysis of 2,439 children with type 1; a large analysis of about 7,600 children from a population-based, multicenter study in five U.S. states; and a retrospective cohort study using data on more than 100,000 patients enrolled in the Diabetes Prospective Follow-up Registry.

Disclosures: SEARCH is funded by the Centers for Disease and Prevention and the National Institute of Diabetes and Digestive and Kidney Diseases. The DPV Registry is funded by multiple sponsors, including the European Federation for the Study of Diabetes and other academic institutions, with the support of several commercial partners. Sanofi sponsored the study presented by Dr. Ibald-Mulli. Dr. Rewers made no disclosures, and Dr. Jensen did not have any conflicts of interest to declare. Dr. Ibald-Mulli is an employee of Sanofi.


Rewers A et al. EASD 2019, Abstract 115; Jensen E et al. EASD 2019, Abstract 116; Ibald-Mulli A et al. EASD 2019, Abstract 117.