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AD Linked with Impaired Sleep in Children

JAMA Pediatrics; ePub 2019 Mar 4; Ramirez, et al

Atopic dermatitis (AD) appeared to be associated with impaired sleep quality throughout childhood, according to a recent study. Therefore, it is suggested that clinicians should consider sleep quality among all children with AD, especially those with comorbid asthma or allergic rhinitis and severe disease, and that interventions to improve sleep quality are needed. Researchers conducted a longitudinal cohort study of children (n=13,988) alive at 1 year and followed up with repeated measures of self-reported AD and sleep through age 16 years. They found:

  • The total sample (7,220 male [51.6%]) was followed up for a median (interquartile range [IQR]) duration of 11 (5-14) years.
  • 4,938 children (35.3%) met the definition of having AD between aged 2 and 16 years.
  • Total sleep duration was similar between children with active AD and without AD at all ages, and the average estimated difference across childhood was a clinically negligible difference of 2 minutes less per day for children with AD.
  • In contrast, children with active AD were more likely to report worse sleep quality at every time point, with a nearly 50% higher odds of experiencing more sleep-quality disturbances.

Ramirez FD, Chen S, Langan SM, et al. Association of atopic dermatitis with sleep quality in children. [Published online ahead of print March 4, 2019]. JAMA Pediatrics. doi:10.1001/jamapediatrics.2019.0025.