Key clinical point: Despite guidelines, volume expansion in children with shock, if performed at all, should be performed with caution.
Major finding: Hemoglobin concentrations were lower in those who received fluid than in those who did not; fluid resuscitation was also associated with lower bicarbonate and increased base deficit and chloride at 24 hours.
Study details: Post hoc analysis of published FEAST trial data and four other data sets.
Disclosures: Authors report no potential conflicts of interest.
Levin M et al. Lancet Respir Med. 2019;7:581-93.