Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

New analysis challenges fluid resuscitation guidelines for patients in shock

Key clinical point: Despite guidelines, volume expansion in children with shock, if performed at all, should be performed with caution.

Major finding: Hemoglobin concentrations were lower in those who received fluid than in those who did not; fluid resuscitation was also associated with lower bicarbonate and increased base deficit and chloride at 24 hours.

Study details: Post hoc analysis of published FEAST trial data and four other data sets.

Disclosures: Authors report no potential conflicts of interest.


Levin M et al. Lancet Respir Med. 2019;7:581-93.