Clinical Edge

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Statins in children cut long-term CVD risk in familial hypercholesterolemia

Key clinical point: Statins started in childhood for patients with familial hypercholesterolemia can reduce carotid thickening and cut the risk of cardiovascular disease.

Major finding: Follow-up LDL cholesterol levels at 20 years for those with familial hypercholesterolemia dropped 32% from baseline in the original study, compared with a 24% increase in the unaffected siblings.

Study details: A 20-year follow-up study of 184 patients with familial hypercholesterolemia and 77 unaffected siblings who had participated in a 2-year, placebo-controlled statin trial.

Disclosures: The study was supported by a grant from the AMC Foundation. The study authors reported disclosures related to numerous pharmaceutical companies and government, nonprofit, or academic entities.


Kastelein JJP et al. N Engl J Med. 2019;381:1547-56.