Tape strips provide a minimally invasive alternative for serially evaluating atopic dermatitis (AD)-associated cutaneous biomarkers, and may prove beneficial for tracking pediatric AD therapeutic response and predicting futures course and comorbidities. This according to a cross-sectional study of 51 children aged <5 years with moderate-to-severe AD and children without AD. 16 tape strips were serially collected from the nonlesional and lesional skin of 21 children who had AD and were <6 months from disease initiation and from the normal skin of 30 children who did not have AD. Gene and protein expression were evaluated. Researchers found:
- 77 of 79 evaluated immune and barrier gene products were detected in 70 of 71 tape strips, with 53 or 79 markers differentiating between children with lesional and/or nonlesional AD from children without AD.
- Many cellular markers of T cells, AD-related dendritic cells, and key inflammatory, innate, helper T cell, and TH17/TH22 genes were significantly increased in lesional and nonlesional AD compared with tape strips from normal skin.
Guttman-Yassky E, et al. Use of tape strips to detect immune and barrier abnormalities in the skin of children with early-onset atopic dermatitis. [Published online ahead of print October 9, 2019]. JAMA Dermatol. doi: 10.1001/jamadermatol.2019.2983.