In a cohort study that evaluated longitudinal disease control and persistence with respect to atopic dermatitis (AD) onset age, early-, mid-, and late-onset pediatric AD appeared to be clinically distinct subtypes of the disease. The study was performed using the Pediatric Eczema Elective Registry, a prospective observational cohort of individuals with childhood-onset AD. AD control and persistence were assessed biannually for up to 10 years. Researchers found:
- 8,015 participants with 41,934 person-years of follow-up were included.
- In longitudinal analyses, older AD onset age was associated with better disease control and less persistent AD.
- Differences in AD control and persistence among early-, mid-, and late-onset AD were most pronounced from early adolescence onward.
Wan, et al. Longitudinal atopic dermatitis control and persistence vary with timing of disease onset in children: A cohort study. [Published online ahead of print May 11, 2019]. J Am Acad Dermatol. doi:10.1016/j.jaad.2019.05.016.